Tonus Therapeutics

Tonus Therapeutics
8210 Golden Oak Circle
Williamsville NY 14221


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Alessandri-Haber, N., O.A. Dina, X.J. Chen, and J.D. Levine. 2009. TRPC1 and TRPC6 Channels Cooperate with TRPV4 to Mediate Mechanical Hyperalgesia and Nociceptor Sensitization. Journal of Neuroscience 29:6217-6228.

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Ateya, D.A., F. Sachs, P.A. Gottlieb, S. Besch, and S.Z. Hua. 2005. Volume cytometry: Microfluidic sensor for high-throughput screening in real time. Analytical Chemistry 77:1290-1294.

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Barone, T.G., P.;Murphy,Y.K.;Sachs,F., Plunkett,R.J. 2008. A Peptide from Tarantula Venom Enhances NGF Induced Neurite Production in Dopaminergic PC12 Cells. American Society for Neural Therapy and Repair

Besch, S.R., T. Suchyna, and F. Sachs. 2002. High-speed pressure clamp. Pflugers Archiv-European Journal of Physiology 445:161-166.

Bett, G.C.L., and F. Sachs. 2000. Whole-cell mechanosensitive currents in rat ventricular myocytes activated by direct stimulation. J Membr.Biol. 173:255-263.

Beyder, A., C. Spagnoli, and F. Sachs. 2006. Reducing probe dependent drift in atomic force microscope with symmetrically supported torsion levers. Review of Scientific Instruments 77:

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Bode, F., F. Sachs, and M.R. Franz. 2001. Tarantula peptide inhibits atrial fibrillation. Nature 409:35-36.

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Bowman, C.L., P.A. Gottlieb, T.M. Suchyna, Y.K. Murphy, and F. Sachs. 2007. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: History, properties, mechanisms and pharmacology. Toxicon 49:249-270.

Brown, A.E.X., R.I. Litvinov, D.E. Discher, and J.W. Weisel. 2007. Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM. Biophysical Journal 92:L39-L41.

Calabrese, B., I.V. Tabarean, P. Juranka, and C.E. Morris. 2002. Mechanosensitivity of N-type calcium channel currents. Biophys J 83:2560-2574.

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Charras, G.T., C.K. Hu, M. Coughlin, and T.J. Mitchison. 2006. Reassembly of contractile actin cortex in cell blebs. J Cell Biol 175:477-490.

Chemin, J., A.J. Patel, P. Delmas, F. Sachs, M. Lazdunski, and E. Honore. 2007a. Regulation of the mechano-gated K-2P channel TREK-1 by membrane phospholipids. Mechanosensitive Ion Channels, Pt B 59:155-170.

Chemin, J., A.J. Patel, F. Duprat, F. Sachs, M. Lazdunski, and E. Honore. 2007b. Up- and down-regulation of the mechano-gated K-2P channel TREK-1 by PIP2 and other membrane phospholipids. Pflugers Archiv-European Journal of Physiology 455:97-103.

Chemin, J., F. Sachs, A.A. Patel, M. Lazdunski, and E. Honore. 2007c. Polymodal regulation of the mechano-gated K 2P  channel TREK-1 by PIP 2  and other membrane phospholipids. Current Topics in Membranes and Transport

Chen, Y., S.M. Simasko, J. Niggel, W.J. Sigurdson, and F. Sachs. 1996. Ca 2+  uptake in GH3 cells during hypotonic swelling: the sensory role of stretch-activated ion channels. American Journal of Physiology 270:C1790-C1798.

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Craig, D., M. Gao, K. Schulten, and V. Vogel. 2004a. Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under force. Structure 12:2049-2058.

Craig, D., M. Gao, K. Schulten, and V. Vogel. 2004b. Tuning the mechanical stability of fibronectin type III modules through sequence variations. Structure 12:21-30.

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Emtage, L., G. Gu, E. Hartwieg, and M. Chalfie. 2004. Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons. Neuron 44:795-807.

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Evans, E.A. 1985. Detailed mechanics of membrane-membrane adhesion and separation. I. Continuum of molecular cross-bridges. Biophys J 48:175-183.

Feng, Q., A. Auerbach, and F. Sachs. 1997. Maximum likelihood estimation of aggregated Markov processes. Proc R Soc Lond B Biol Sci 264:375-383.

Franco-Obregon, A., and J.B. Lansman. 2002. Changes in mechanosensitive channel gating following mechanical stimulation in skeletal muscle myotubes from the mdx mouse. Journal of Physiology 539:391-407.

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Gottlieb, P., R. Maroto, A. Raso, T.G. Wood, A. Kurosky, B. Martinac, O. Hamill, C.B. Bowman, J.H.A. Folgering, A. Patel, F. Sachs, and E. Honore. 2007. Revisiting TRPC1 mechanosensitivity Pflugers Arch

Gottlieb, P.A., T. Barone, F. Sachs, and R. Plunkett. 2010. Neurite outgrowth from PC12 cells is enhanced by an inhibitor of mechanical channels. Neuroscience Letters 481:115-119.

Gu, C.X., P.F. Juranka, and C.E. Morris. 2001. Stretch-activation and stretch-inactivation of Shaker-IR, a voltage- gated K+ channel. Biophys J 80:2678-2693.

Guharay, F., and F. Sachs. 1984. Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. Journal of Physiology (London) 352:685-701.

Guharay, F., and F. Sachs. 1985. Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH. Journal of Physiology (London) 353:119-134.

Hamill, O.P., and B. Martinac. 2001. Molecular basis of mechanotransduction in living cells. Physiological Reviews 81:685-740.

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Honore, E., T. Suchyna, A.A. Patel, and F. Sachs. 2006. Desensitization of cloned 2P domain K channels. Proceedings of the National Academy of Sciences 103:6859-6864.

Hua, S.Z., P.A. Gottlieb, J. Heo, and F. Sachs. 2010. A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol 298:C1424-1430.

Hudspeth, A.J., Y. Choe, A.D. Mehta, and P. Martin. 2000. Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells. Proc Natl.Acad.Sci U.S A 97:11765-11772.

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Kockskamper, J., M. Khafaga, M. Grimm, A. Elgner, A. Lauterbach, D. von Lewinski, H. Dorge, P. Gottlieb, F. Sachs, T. Eschenhagen, and F.A. Schondube. 2007a. Acute stretch stimulates myosin light chain kinase to elicit a delayed increase in force via a pH-independent increase in myofilament Ca 2+  responsiveness in human atrial myocardium. In.

Kockskamper, J., D. von Lewinski, M. Khafaga, A. Elgner, M. Grimm, T. Eschenhagen, F. Sachs, and B. Pieske. 2007b. The slow force response to stretch in atrial and ventricular myocardium from human heart - functional relevance and subcellular mechanisms Progress in Biophysics and Molecular Biology

Kohl, P., F. Sachs, and M.R. Franz. 2005. Cardiac Mechano-Electric Feedback and Arrhythmias; from pipette to patient. Elsevier, Philadelphia.

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Markin, V., and F. Sachs. 2006. Thermodynamics of mechanosensitivity. Current Topics in Membranes and Transport

Markin, V.S., and F. Sachs. 2004. Thermodynamics of mechanosensitivity. Physical Biology 1:110-124.

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Meng, F., and F. Sachs. 2011a. Measuring strain of structural proteins in vivo in real time. In Cardiac Mechano-Electric Coupling and Arrhythmia: From Pipette to Patient. P. Kohl, F. Sachs, and M.R. Franz, editors. Oxford University Press, Oxford.

Meng, F., T. Suchyna, E. Lasalovitch, R.M. Gronostajski, and F. Sachs. 2011. Real time FRET based detection of mechanical stress in cytoskeletal proteins. Cellular and Molecular Bioengineering (in press):

Meng, F., T.M. Suchyna, and F. Sachs. 2008. A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J 275:3072-3087.

Meng, F.J., and F. Sachs. 2011b. Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J. Cell Sci. 124:261-269.

Michele, D.E., and K.P. Campbell. 2003. Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function. J Biol Chem 278:15457-15460.

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Niggel, J., and F. Sachs. 2007. Cytoskeletal proteins play a minor role in mechanotransduction in rat astrocytes and COS7L cells. Biophysical Journal 112A-112A.

Niu, W.Z., and F. Sachs. 2003. Dynamic properties of stretch-activated K+ channels in adult rat atrial myocytes. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 82:121-135.

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Ostrow, K.L., A. Mammoser, T. Suchyna, F. Sachs, R.E. Oswald, S. Kubo, N. Chino, and P. Gottlieb. 2003. cDNA sequence and  in vitro  folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon 42 263-274.

Ostrow, L., and F. Sachs. 2005. Mechanosensation and Endothelin in Astrocytes - potential roles in reactive gliosis. Brain Research Reviews 48:488-508.

Ostrow, L.W. 2003. Mechanosensation and Endothelin in Astrocytes [Thesis/Dissertation]. In State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Department of Physiology and Biophysics 

Oswald, R.E., T.M. Suchyna, R. McFeeters, P. Gottlieb, and F. Sachs. 2002. Solution structure of peptide toxins that block mechanosensitive ion channels. Journal of Biological Chemistry 277:34443-34450.

Pajerowski, J.D., K.N. Dahl, F.L. Zhong, P.J. Sammak, and D.E. Discher. 2007. Physical plasticity of the nucleus in stem cell differentiation. Proceedings of the National Academy of Sciences of the United States of America 104:15619-15624.

Park, S.J., M.B. Goodman, and B.L. Pruitt. 2007. Analysis of nematode mechanics by piezoresistive displacement clamp. Proc Natl Acad Sci U S A 104:17376-17381.

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Parker, K.K., and D.E. Ingber. 2007. Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philosophical Transactions of the Royal Society B-Biological Sciences 362:1267-1279.

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Perozo, E., D.M. Cortes, P. Sompornpisut, A. Kloda, and B. Martinac. 2002a. Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Nature 418:942-948.

Perozo, E., A. Kloda, D.M. Cortes, and B. Martinac. 2002b. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Nature Structural Biology 9:696-703.

Posokhov, Y.G., A. Freites, P. Gottlieb, F. Sachs, and A.S. Ladokhin. 2008. Experimental and Molecular Dynamics (MD) Characterization of Membrane Interactions of the Cysteine Knot (CK) Family of Ion-Channel Blockers Biophysical Journal

Posokhov, Y.O., P.A. Gottlieb, M.J. Morales, F. Sachs, and A.S. Ladokhin. 2007. Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers? Biophysical Journal 93:L20-L22.

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Sachs, F. 2010. Stretch activated Ion Channels; What are They. Physiology 25:6.

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Sarkar, A., S. Caamano, and J.M. Fernandez. 2005. The elasticity of individual titin PEVK exons measured by single molecule atomic force microscopy. J Biol Chem 280:6261-6264.

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Suchyna, T., and F. Sachs. 2004. Dynamic Regulation of Mechanosensitive Channels; Capacitance Used to Monitor Patch Tension in Real Time. Physical Biology 1:1-18.

Suchyna, T., and F. Sachs. 2007a. Mechanical and electrical properties of membranes from dystrophic and normal mouse muscle. J.Physiol.(Lond) 581:369-387.

Suchyna, T., and F. Sachs. 2007b. Properties of the gigaseal. In.

Suchyna, T., and F. Sachs. 2008. Properties of the gigaseal. In.

Suchyna, T.M., J.H. Johnson, K. Hamer, J.F. Leykam, D.A. Gage, H.F. Clemo, C.M. Baumgarten, and F. Sachs. 2001. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels (vol 115, pg 583, 2000). Journal of General Physiology 117:371-371.

Suchyna, T.M., V.S. Markin, and F. Sachs. 2009. Biophysics and structure of the patch and the gigaseal. Biophys J 97:738-747.

Suchyna, T.M., and F. Sachs. 2007c. Adhesion energy of gigaseal and cytoskeletal effects on patch dome strength. Biophysical Journal 113A-113A.

Suchyna, T.M., and F. Sachs. 2007d. Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes. J Physiol 581:369-387.

Suchyna, T.M., S.E. Tape, R.E. Koeppe, 2nd, O.S. Andersen, F. Sachs, and P.A. Gottlieb. 2004a. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature 430:235-240.

Suchyna, T.M., S.E. Tape, R.E. Koeppe, O.S. Andersen, F. Sachs, and P.A. Gottlieb. 2004b. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature 430:235-240.

Sukharev, S., and A. Anishkin. 2004. Mechanosensitive channels: what can we learn from 'simple' model systems? Trends in Neurosciences 27:345-351.

Sukharev, S., W. Sigurdson, C. Kung, and F. Sachs. 1999. Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL  Journal of General Physiology 113:525-539.

Tan, J.H., W. Liu, and D.A. Saint. 2004. Differential expression of the mechanosensitive potassium channel TREK-1 in epicardial and endocardial myocytes in rat ventricle. Exp Physiol 89:237-242.

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Vandorpe, D.H., C. Xu, B.E. Shmukler, L.E. Otterbein, M. Trudel, F. Sachs, P.A. Gottlieb, C. Brugnara, and S.L. Alper. 2010. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. Plos One 5:e8732.

Walther, K.A., J. Brujic, H. Li, and J.M. Fernandez. 2006. Sub-angstrom conformational changes of a single molecule captured by AFM variance analysis. Biophys J 90:3806-3812.

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Whitehead, N.P., M. Streamer, L.I. Lusambili, F. Sachs, and D.G. Allen. 2006. Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice. Neuromuscul Disord 16:845-854.

Wiggins, P., and R. Phillips. 2005. Membrane-protein interactions in mechanosensitive channels. Biophysical Journal 88:880-902.

Yeung, E.W., N.P. Whitehead, T.M. Suchyna, P.A. Gottlieb, F. Sachs, and D.G. Allen. 2005. Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse. Journal Of Physiology-London 562:367-380.

Zhao, F., L. Dong, L. Cheng, Q. Zeng, and F. Su. 2007. Effects of acute mechanical stretch on the expression of mechanosensitive potassium channel TREK-1 in rat left ventricle. J Huazhong Univ Sci Technolog Med Sci 27:385-387.